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Anolder adult frequently presents with anemia from no appar-ent cause. These benefits are somewhatenhanced with cognitive “booster” training sessions follow-ing the initial intervention.

With the use of special techniques,metallic artifacts can be minimized [38]. This interaction of p53 with RAD51 and subsequent inhibition ofrecombination was further conrmed by overexpressing mutant L186PRAD51 thatprevented p53 binding to RAD51 [43].

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Inability to sustainblood pressure and accumulation of fluid in the lungs mayalso result. Nagtegaal ID, van de Velde CJ, Marijnen CA, van Krieken JH, Quirke P.

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[ 121] studied the DNA methylation status of both P1and P2 promoters as a means of epigenetic transcriptional control of their corre-sponding isoforms in 102 primary NSCLCs and reported that the P2 hypomethylation-associated overexpression of ??p73 mRNA is a frequent event, particularly amongsquamous cell carcinomas. Cog-nitive impairments affecting executive control have beenlinked to reduced vasodilation, with pronounced effects onfrontal–subcortical circuits that are particularly susceptibleto insulin-dependent microvascular changes in vulnerableareas with watershed arteriole architecture (Campbell andCoffey, 2001).

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